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Chainalysis: Gray-market peptide suppliers accelerate shift to Bitcoin and stablecoins, with Q1 crypto inflows surging 159% year-on-year

According to The Block, blockchain analytics firm Chainalysis’ latest report states that as the gray-market peptide industry’s scale exceeds an annualized $100 million, leading suppliers are accelerating adoption of Bitcoin and stablecoins as primary settlement instruments. In Q1 2026, cryptocurrency inflows into this industry reached $32 million—a 159% quarter-on-quarter surge. Due to widespread bans imposed by traditional banks and credit card payment channels on prescription-grade compounds and unregulated substances, numerous Chinese chemical manufacturers have turned to cryptocurrencies for transactions, with high-value orders especially favoring stablecoins to hedge against price volatility risk.

Bitwise CIO: The crypto market is shifting from momentum trading to contrarian bets; further sustained rallies in major cryptocurrencies await legislative clarity.

According to The Block, Bitwise CIO Matt Hougan noted in his latest weekly report that as the Nasdaq-100 Index has surged 43% year-to-date and AI-related stocks continue attracting capital, the crypto market is undergoing a shift—from “momentum trading” to “contrarian bets.” Investors must adopt a long-term perspective and focus on fundamentals. Hougan also observed that during this crypto winter, capital has not flowed into mainstream safe-haven assets like Bitcoin; instead, it has poured into mid- and small-cap tokens with distinctive narratives—such as Hyperliquid (up 72% month-to-date), Zcash (up 50%), and Stellar (up 44%). Additionally, he emphasized that uncertainty surrounding the Clarity Act—a proposed legislative framework for crypto market structure—remains a key constraint on institutional capital inflows. Galaxy analysts and Polymarket both estimate the bill’s passage probability at roughly 50–55%. A sustainable rally in major crypto assets may only materialize after the legislation is enacted.

Grayscale Files for Hyperliquid ETF with Fee Rate 0.29% Lower Than Comparable Competitors

According to The Block, Grayscale filed an amendment to its S-1 registration statement with the U.S. Securities and Exchange Commission (SEC) on Monday for the Hyperliquid Staking ETF (ticker: HYPG), setting its management fee at 0.29%—lower than the already-listed Bitwise BHYP (0% for the first month, then 0.34%) and 21Shares THYP (0.30%). James Seyffart, ETF analyst at Bloomberg Intelligence, stated that the fund is expected to officially launch this week. Hyperliquid is a decentralized derivatives exchange supporting on-chain perpetual contract trading; its native token, HYPE, has a market capitalization of approximately $16.1 billion, ranking it as the world’s tenth-largest crypto asset.

Analysis: Bitcoin Drops Near $72,000 as Institutional Funds Flow Out Consecutively, Weighing on Market Sentiment

According to The Block, Bitcoin fell nearly to $72,000 on Monday. U.S. spot Bitcoin ETFs have recorded net outflows for 10 consecutive trading days, totaling approximately $2.97 billion. For the week ending May 25–29, U.S. spot Bitcoin ETFs saw weekly outflows of $1.42 billion, while global cryptocurrency ETPs recorded $1.67 billion in outflows during the same period.

Hypernova completes $3 million pre-seed round, led by Lemniscap

Hypernova has announced the completion of a $3 million pre-seed funding round, led by Lemniscap, with participation from Very Early Ventures, CMS Holdings, Pivot Global, and multiple angel investors from the Hyperliquid ecosystem.The project's main business is building a proprietary trading platform on Hyperliquid, using smart contracts to automate trader payouts, and dynamically determining whether to push positions to market based on trader quality. (The Block)

Sequans Exits Bitcoin Treasury Strategy, Completes Debt Redemption and Refocuses on IoT Chip Business

Odaily Odaily French semiconductor company Sequans Communications stated on Thursday that it has completed the redemption of all debt related to its Bitcoin treasury, marking its official exit from the previous crypto asset treasury strategy and a refocus on the Internet of Things (IoT) and cellular semiconductor business. The company stated that this debt repayment was mainly completed by selling approximately 80% of its Bitcoin holdings. Sequans currently holds only 658 BTC, which are now “completely unencumbered.” The company said it will gradually “monetize” the remaining Bitcoin in the future, but did not specify whether it will continue selling or use on-chain methods such as collateralization.Sequans CEO Georges Karam stated that this debt cleanup “marks an important turning point,” with the company having strengthened its balance sheet, simplified its capital structure, and will now fully concentrate on the 4G/5G IoT chip business, including applications such as smart metering, asset tracking, connected vehicles, and industrial IoT.In retrospect, Sequans initiated its Bitcoin treasury strategy in June 2025, planning to substantially increase its BTC holdings. However, it gradually reduced its position amid market fluctuations, ultimately exiting the strategy entirely during the current cycle. Although the company's stock price saw a slight increase on the day, it has cumulatively fallen by over 90% from its peak during the Bitcoin boom. (The Block)

Liquid Launches Co-Invest App, Enabling Users to Execute Live Trades Directly Within ChatGPT and Claude

According to The Block, multi-asset trading platform Liquid launched its Co-Invest application on Tuesday, enabling users to directly top up their accounts, conduct market analysis, and execute live trades within the ChatGPT and Claude chat interfaces—without leaving the AI assistant.

TD Cowen: Deteriorating Political Environment Reduces Likelihood of US Crypto Market Structure Bill Passing This Year

Investment bank TD Cowen stated that as the relevant political environment continues to deteriorate, the likelihood of the US crypto market structure bill, the "Clarity Act," passing this year is declining.TD Cowen analyst Jaret Seiberg pointed out that while the Senate Banking Committee advanced the bill earlier this month, this does not signify a substantive bipartisan agreement; rather, it merely pushes the controversy to the full Senate floor.The report indicated that the escalating controversies surrounding US President Donald Trump and his administration related to crypto in recent days are making it harder for Democrats to support the bill. If the bill does not include clear conflict-of-interest provisions, it will face even greater difficulty in gaining sufficient support in the current political environment.

Analyst: Significant institutional fund rotation in Bitcoin; institutional demand remains intact

According to The Block, Bitcoin continued trading below $78,000 on Monday, following net outflows of $1.26 billion from spot Bitcoin ETFs during the week of May 18–22—the second consecutive week of outflows exceeding $1 billion. Nevertheless, Timothy Misir, Research Head at BRN, noted that institutional demand has not vanished but is rotating: during the same period, the XRP ETF attracted $22 million in inflows, the Solana ETF drew $16 million, the newly launched Hyperliquid HYPE ETF garnered $72 million, while the Ethereum ETF saw outflows of $216 million. Ethereum also faced pressure due to the SEC’s delay of its tokenized stock trading initiative, though it posted a modest rebound on Sunday amid heightened optimism surrounding the Iran deal. On the options front, for Bitcoin expiring on May 29, the largest open interest concentrations were at the $75,000 put and $80,000 call strikes; for Ethereum, the largest open interest concentration was at the $2,100 put strike. On the macro front, U.S. and European markets were closed for public holidays, and analysts warned of low market liquidity. Should the Iran deal materialize, it could trigger a sharp drop in oil prices and push equity markets to new highs.

Ethereum Layer 2 project Zero Network announces shutdown; multiple protocols cease operations in succession

According to The Block, Ethereum Layer 2 project Zero Network has announced its imminent official shutdown—just about 1.5 years after launch. Launched by the Zerion team in November 2024, Zero Network positioned itself as the first EVM-compatible rollup offering fully gas-free transactions, aiming to lower barriers to entry and drive mainstream adoption. The team stated it will now focus its resources on Zerion’s API and wallet business. Users must bridge their NFTs, ETH, and other tokens out of the Zero Network by the end of July; the bridge’s deposit functionality is currently suspended.

JPMorgan: Tokenized money market funds struggle to surpass the 15% market share ceiling of stablecoins

According to The Block, JPMorgan analysts noted in their latest report that tokenized money market funds currently account for only about 5% of the stablecoin market size and are expected to continue growing—but unless there is a significant shift in the regulatory environment, they are unlikely to surpass a market share ceiling of 10%–15%. The analysts believe stablecoins remain the preferred cash instrument in the crypto ecosystem due to their widespread use in trading, settlement, cross-border payments, and liquidity management. In contrast, tokenized money market funds—classified as securities—are subject to structural regulatory disadvantages, including requirements for registration, disclosure, and transfer restrictions, making them difficult to circulate freely within on-chain ecosystems. Although the U.S. SEC has introduced streamlined processes for issuing on-chain money market funds, JPMorgan analysts view this as only a “marginal improvement,” insufficient to fundamentally alter the market dynamics between these two asset classes.

Analysis: BTC Unlikely to Hold Above $80,000 in the Short Term, Weak Spot Demand Curbs Breakout Expectations

Odaily Bitcoin fell below $78,000 on Thursday, with growing concerns over the sustainability of any rebound. Data shows that Bitcoin spot ETFs have recorded net outflows for four consecutive trading days, while approximately $584 million in long liquidations earlier this week continues to suppress market risk appetite. Analysts suggest that until on-chain spot demand recovers, BTC will still struggle to firmly hold above $80,000 in the short term.The pressure on the Ethereum market is even more pronounced. The ETH spot ETF saw net outflows of $28.1 million on the day, marking eight consecutive trading days of withdrawals. Since May 7, ETH ETFs have seen cumulative outflows of approximately $504 million over nine trading days, the most severe sustained capital exodus since February this year.In the derivatives market, total crypto futures liquidation volume reached approximately $657 million this Monday, with long liquidations accounting for $584 million, the largest single-day long squeeze event since early February. The current Bitcoin open interest has fallen about 14% from its May 6 peak, but the overall leverage structure has not yet been fully reset.On-chain data also leans bearish. Glassnode indicates that Bitcoin's previous rebound to $82,000 briefly reclaimed the key level of $78,300, the "realized market average," but has since fallen back below it. Historical cycles suggest that BTC typically needs to consolidate in this range for weeks to months to confirm a structural shift between bull and bear markets.Additionally, Glassnode data shows that Bitcoin's spot CVD (Cumulative Volume Delta) has been negative for nine consecutive trading days, marking the longest net selling cycle since 2026. Meanwhile, BTC's hourly spot trading volume has declined about 40% compared to the same period in 2025. Analysis indicates that U.S. investors have been consistently distributing their holdings since Q4 2025, while Asian capital has shifted to accumulation.The options market is also signaling caution. The BTC short-term 25-delta skew has risen from 2.7% to 6.2%, indicating a significant increase in market demand for downside protection. A large gamma short position of approximately $2.5 billion is concentrated around the $75,000 strike price. Should BTC fall back to this area, hedging by market makers could further amplify volatility.In the altcoin market, the sector is largely following BTC, with Bitcoin's dominance remaining around 60%. However, Hyperliquid and Zcash have bucked the trend with double-digit gains, suggesting selective rotation by some capital. (The Block)

Hyperliquid ETF records record single-day net inflow of $25.5 million

According to The Block, U.S. spot HYPE ETFs recorded $25.5 million in net inflows on Wednesday—the highest single-day figure since launch—surging significantly from $11 million on Tuesday. Specifically, the 21Shares Hyperliquid ETF (THYP) saw $16.7 million in daily inflows, while the Bitwise Hyperliquid ETF (BHYP) attracted $8.8 million. Since its May 12 launch, net inflows have totaled $54 million over seven trading days.

Hyperliquid ETF Attracts $22.3 Million in First Week, Analysis Shows Growth in "Real Institutional Demand"

the spot ETF product associated with Hyperliquid recorded approximately $22.3 million in net inflows during its first week of trading. Market analysts believe this reflects strong institutional demand and the expansion of the on-chain derivatives ecosystem. Data shows that Hyperliquid currently captures over 42% of the fee share in the on-chain derivatives market, significantly ahead of the Ethereum and Solana ecosystems. Analysts suggest that the token (HYPE) buyback and burn mechanism further amplifies the transmission effect of ETF fund flows on price. (The Block)Previously reported, Bloomberg ETF analyst Eric Balchunas stated that the continued rise in THYP trading volume is "a positive signal of increasing organic demand" and noted that Hyperliquid's high fee revenue may be a key factor attracting investor attention.

K33: Current market trends differ from past bear market rallies, $60,000 Bitcoin may be the cycle bottom

crypto research firm K33 stated that although Bitcoin has retested its 200-day moving average around $82,000 this month and subsequently fallen by about 6%, the low near $60,000 in February this year may still represent the maximum drawdown of this cycle. K33 Research Head Vetle Lunde pointed out that unlike the bear market rallies in 2014, 2018, and 2022, this market experienced a slow recovery lasting 189 days after breaking below the 200-day moving average. Furthermore, market leverage and risk appetite have not been quickly rebuilt. Therefore, the current trend resembles a moderate correction rather than a precursor to another sharp decline.K33 also noted that institutional fund flows still reflect a defensive sentiment. The latest 13F filings show that institutional investors reduced their holdings by a total of approximately 26,733 BTC in the first quarter, while retail investors increased their holdings by about 19,395 BTC. Neutral strategy institutions like Jane Street and Millennium accounted for most of this reduction. Additionally, Bitcoin ETFs recently recorded the ninth-largest five-day capital outflow since the launch of U.S. spot ETFs. K33 believes this typically occurs when BTC is near the cost basis of ETF holdings, reflecting investors' tendency to cut losses or reduce risk exposure after experiencing significant drawdowns. (The Block)

ARK Invest Bought $4.4 Million Worth of Bullish Stocks This Week

According to The Block, Cathie Wood’s ARK Invest purchased a total of 122,020 shares of Bullish (BLSH) stock through its ARKK, ARKW, and ARKF ETFs on Monday and Tuesday this week, with a total value of approximately $4.4 million. Prior to this, Bullish’s stock price had fallen 15.4% over the past five trading days; it rebounded slightly by 1.88% on Tuesday to close at $36.23, but remained down 16.7% over the past month.

Wall Street analysts upgraded ratings for several crypto companies, believing the market has undervalued their AI infrastructure and capital markets transformation potential.

According to The Block, three Wall Street firms—Benchmark, TD Cowen, and Mizuho—maintained “Buy” ratings on four crypto-related companies—Bitdeer, DeFi Technologies, Strive, and Gemini—on Monday, noting that the market continues to value these platforms, which have pivoted toward AI infrastructure, capital markets tools, and structured financial products, using trading-business valuation multiples. Benchmark analysts reiterated their “Buy” rating on Bitdeer and $27 price target, highlighting its global power asset portfolio of approximately 3.0 GW and the growth of its AI cloud business’s annual recurring revenue—from roughly $10 million at the end of January to approximately $69 million by the end of April. TD Cowen raised its price target for Strive to $30, forecasting a 26.1% Bitcoin yield for the company in 2026. Mizuho maintained its “Outperform” rating on Gemini but lowered its price target from $12 to $10, noting that although Q1 trading volume declined by over 50%, trading revenue remained largely flat—reflecting higher fee rates and an optimized revenue mix.

Analysis: Bitcoin Drops Below $77,000 as Geopolitical Conflicts and Inflation Concerns Trigger Sell-Off

Bitcoin has fallen below the $77,000 mark, hitting a low of approximately $76,720. Analysts attribute the market decline primarily to multiple macroeconomic pressures, including the renewed escalation of tensions between the US and Iran, rising inflation concerns, and increased risk aversion across risk assets. Former US President Donald Trump issued a strong warning to Iran on social media, intensifying geopolitical uncertainty.Meanwhile, rising oil prices have further elevated inflation expectations, with Brent crude climbing to around $111 and WTI rising above $107. This has sparked concerns that the Federal Reserve may maintain higher interest rates for a longer period.The current selling pressure is also compounded by factors such as rising US Treasury yields, a strengthening US dollar, and ETF outflows. Data shows that Bitcoin ETFs saw net outflows of approximately $1 billion in the week ending May 17, ending six consecutive weeks of net inflows.In terms of market sentiment, the Bitcoin Fear and Greed Index has fallen back to 27, re-entering the "fear zone." Analysts believe that short-term trends will remain highly dependent on macroeconomic data and policy expectations. However, some institutions view the current correction as a "healthy digestion" period, suggesting the long-term structure remains unchanged. (The Block)

Harvard University Liquidates Ethereum ETF; Abu Dhabi Sovereign Wealth Fund Increases IBIT Holdings

several sovereign wealth funds, universities, and traditional financial institutions have recently disclosed their 13F holdings for the first quarter of 2026.Among them, Mubadala, the Abu Dhabi sovereign wealth fund, increased its holdings in the BlackRock iShares Bitcoin Trust ETF (IBIT) from 12.7023 million shares to 14.7219 million shares. The newly added holdings are valued at over $90 million, bringing the total value of its position to nearly $660 million. Meanwhile, its subsidiary, the Abu Dhabi Investment Council (ADIC), maintained its IBIT position unchanged at 8.2187 million shares, worth approximately $315.8 million.Regarding university funds, Harvard University's endowment fund held 3.0446 million shares of IBIT, valued at around $117 million, a reduction of about 43% compared to the end of 2025. Additionally, Harvard completely liquidated its position in the BlackRock Ethereum spot ETF, which was established last quarter and valued at approximately $86.8 million.Furthermore, Dartmouth College maintained its IBIT holdings unchanged and disclosed for the first time holding approximately 304,800 shares of the Bitwise Solana Staking ETF, valued at around $3.67 million, making it one of the first university endowment funds to publicly allocate to a Solana-related ETF.On the traditional financial institution side, institutions such as the Royal Bank of Canada (RBC) and Barclays continued to increase or adjust their IBIT-related spot and options positions, while Hong Kong-based Laurore reduced its IBIT holdings from 8.7863 million shares to 6.8463 million shares. (The Block)

Q1 13F Filings: Abu Dhabi Sovereign Fund Significantly Increases IBIT Stake; Harvard University Fully Exits Ethereum ETF

According to The Block, several sovereign wealth funds, university endowments, and traditional banks disclosed their 13F holdings for Q1 2026: • Mubadala, Abu Dhabi’s sovereign wealth fund, increased its position in the BlackRock iShares Bitcoin Trust ETF (IBIT) from 12.7 million shares to 14.72 million shares—adding over $90 million—bringing its total holding value to approximately $566 million (a 16% increase quarter-on-quarter). Its subsidiary, the Abu Dhabi Investment Council (ADIC), maintained its IBIT position unchanged at 8.21 million shares, valued at approximately $316 million. • University endowments’ crypto ETF holdings remained largely stable. • Traditional financial institutions actively rebalanced their positions: Royal Bank of Canada (RBC) increased its spot IBIT holdings while hedging with put/call options; Scotiabank sold off Trump-related Bitcoin stocks and added 214,000 IBIT shares; Barclays held approximately 4.46 million shares of spot IBIT and deployed a large options position; Hong Kong–based Laurore reduced its IBIT holdings from 8.78 million shares to 6.85 million shares.